Gonadotropin-Releasing Hormone: Regulation of Adenosine 3′,5′-Monophosphate in Ovarian Granulosa Cells
- 18 December 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 214 (4527) , 1346-1348
- https://doi.org/10.1126/science.6274016
Abstract
The antigonadal effects of gonadotropin-releasing hormone in ovarian granulosa cells are due to attenuation of the adenosine 3',5'-monophosphate (cyclic AMP) response to follicle-stimulating hormone. Agonists of gonadotropin-releasing hormone progressively inhibit adenylate cyclase and stimulate phosphodiesterase activities in cultured granulosa cells, indicating that blockade of gonadotropin action is attributable to the combined effects of decreased production and increased degradation of cyclic AMP.This publication has 19 references indexed in Scilit:
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