The Birth of an Alternatively Spliced Exon: 3' Splice-Site Selection in Alu Exons
- 23 May 2003
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 300 (5623) , 1288-1291
- https://doi.org/10.1126/science.1082588
Abstract
Alu repetitive elements can be inserted into mature messenger RNAs via a splicing-mediated process termed exonization. To understand the molecular basis and the regulation of the process of turning intronic Alus into new exons, we compiled and analyzed a data set of human exonized Alus. We revealed a mechanism that governs 3′ splice-site selection in these exons during alternative splicing. On the basis of these findings, we identified mutations that activated the exonization of a silent intronic Alu.Keywords
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