The Problem of Renal Vascular Shunts

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Abstract
In dogs anesthetized with chlorolose, renal clearance studies were done before and after sciatic nerve (sensory) stimulation. No evidence was found to support the hypothesis that renal vascular shunts become functionally active as a result of sensory nerve stimulation. Although the urine vol. decreased, no animals became anuric. The renal plasma flow (p-aminohippuric acid (PAH) clearance) decreased significantly in about 2/3 of the animals. In half of these there was a concomitant decrease in glomerular filtration rate and in the other half it did not change. The filtration fraction consistently increased. In the remaining 1/3 of the dogs there were no observable changes in the renal hemo-dynamics. Renal tubular function as measured by extractions of PAH and maximum glucose transport was not disturbed. Evidently the blood flowing through the kidneys continued to perfuse through the nephrons in a normal manner even though the total blood flow might be decreased. None of the studies suggested that the renal blood bypassed the cortex through juxtamedullary shunts. These observations confirmed previous direct renal blood flow and dye injn. studies.
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