Carbonic Anhydrase

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Abstract
The challenge that led to the discovery of carbonic anhydrase was the paradox that bicarbonate ion (HCO3 -), the carrier of metabolic carbon dioxide, could not deliver carbon dioxide from the tissues or through the lungs at known rates by the reaction1 , 2 The matter was clarified at once when the enzyme for Reaction 1 was isolated from red cells and its properties were characterized.3 It was the first metalloenzyme to be discovered, a water-soluble Zn protein of 30,000 daltons. In the 1930s interest in the subject was slight and largely confined to respiratory physiologists.4 This changed abruptly with the . . .