Therapeutic Strategy in Clinical Immunology

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Abstract
THE control of disease by immunologic means began in 1796, when Edward Jenner inoculated James Phipps with cowpox. Immunologic prophylaxis still flourishes, and the discovery that passive immunization prevents erythroblastosis1 is its latest triumph. Early in this century Clemens von Pirquet initiated another branch of immunology by establishing the principle that antibodies can be injurious. The central issues of clinical immunology, formulated in terms of these momentous discoveries, are the production of desired immunity and the elimination of undesired immune reactions. It is with the latter that this review is concerned.Normal Immune ResponsesStudies of the immune response are . . .