EVIDENCE FOR AN ARENE OXIDE-NIH SHIFT PATHWAY IN THE METABOLIC CONVERSION OF PROPRANOLOL TO 4'-HYDROXYPROPRANOLOL IN THE RAT AND IN MAN
- 1 January 1979
- journal article
- research article
- Vol. 7 (6) , 351-355
Abstract
To determine whether the 4''-hydroxylation of propranolol occurs by an arene oxide-NH shift process, 4''-deuteropropranolol, prepared from 4''-iodopropranolol, was subjected to in vitro metabolic experiments in the rat liver 9000 g supernatant fraction and to in vivo metabolic experiments in man. Deuterium retention in the resulting 4''-hydroxypropranolol, determined by mass spectrometry after gas-or high-pressure liquid-chromatographic separation, was 73-75%. The results are interpreted to indicate that 4''-hydroxylation of propranolol proceeds by way of an arene oxide-NlH shift process in these 2 metabolic systems.This publication has 13 references indexed in Scilit:
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