Radiation Doses resulting from the Administration of Tritiated Folic Acid and Tritiated Water to the Rat

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Abstract
The distribution and retention of radioactivity in various organs of the rat was investigated following injection of tritiated folic acid and, for comparison, tritiated H2O. After an injection of 1 mCi folic acid, liver received the highest dose, about 90 rems, followed by kidney, 65 rems, and bone marrow, 15 rems. For tritiated H2O, the rat body received a fairly uniform dose of about 12 rems/mCi. On the basis of the recommendations of the International Commission on Radiological Protection, it is suggested that tritiated folic acid is about twice as toxic as tritiated H2O.