Double Trouble for Type 1 Angiotensin Receptors in Atherosclerosis
- 3 February 2005
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 352 (5) , 506-508
- https://doi.org/10.1056/nejmcibr043928
Abstract
A recent study suggests that type 1 angiotensin receptors on the surface of monocytes must dimerize — through a mechanism mediated by transglutaminase — to become activated and hence best able to adhere to the vascular endothelium.Keywords
This publication has 5 references indexed in Scilit:
- Factor XIIIA Transglutaminase Crosslinks AT1 Receptor Dimers of Monocytes at the Onset of AtherosclerosisCell, 2004
- G Protein-Coupled Receptor Dimerization: Function and Ligand PharmacologyMolecular Pharmacology, 2004
- Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single AntagonistCirculation, 2003
- Transglutaminases: crosslinking enzymes with pleiotropic functionsNature Reviews Molecular Cell Biology, 2003
- AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestrationNature, 2000