Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery
- 15 March 1997
- Vol. 5 (3) , 319-324
- https://doi.org/10.1016/s0969-2126(97)00189-5
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- Potent Thrombin Inhibitors That Probe the S1‘ Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl GroupJournal of Medicinal Chemistry, 1996
- Combinatorial synthesis — the design of compound libraries and their application to drug discoveryTetrahedron, 1995
- A Transition State Analog Inhibitor Combinatorial LibraryJournal of the American Chemical Society, 1995
- Design and Synthesis of Potent and Highly Selective Thrombin InhibitorsJournal of Medicinal Chemistry, 1994
- Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future DirectionsJournal of Medicinal Chemistry, 1994
- Structure-Based Design of Synthetic Azobenzene Ligands for StreptavidinJournal of the American Chemical Society, 1994
- Drugs by DesignScientific American, 1993
- The solution conformation of (D)Phe-Pro-containing peptides: implications on the activity of Ac-(D)Phe-Pro-boroArg-OH, a potent thrombin inhibitorJournal of Medicinal Chemistry, 1993
- Crystallographic and thermodynamic comparison of natural and synthetic ligands bound to streptavidinJournal of the American Chemical Society, 1992
- Waterlogged MoleculesScience, 1983