Vitamin K-dependent carboxylation: inhibition by a peptide containing 4-methylene glutamic acid
- 5 November 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 177 (2) , 265-268
- https://doi.org/10.1016/0014-5793(84)81296-x
Abstract
The peptide Boc-4-methylene Glu-Glu-Val has been synthesized and shown to be a strong inhibitor of the vitamin K-dependent carboxylation catalyzed by a detergent solubilized rat liver microsome preparation. The inhibition is apparently competitive with respect to the substrate peptide and non-competitive with respect to HCO3−Vitamin KCarboxylation4-Methylene glutamic acidγ-Carboxyglutamic aciKeywords
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