Hormone Excretion before and after Castration and Adrenalectomy

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Abstract
FOURTEEN years have passed since Huggins and Hodges1 demonstrated the efficacy of castration and estrogen therapy in the treatment of carcinoma of the prostate. The frequently observed response of this malignant process to hormonal therapy remains the most striking and promising phenomenon yet discovered in the study of cancer. However, the exact biologic mechanisms whereby retrogression of the neoplastic cell is brought about have not been elucidated. Further studies of the metabolic processes resulting from changes in hormonal environment will help define these mechanisms. In the first place it is indicated to measure the hormonal changes that occur during the . . .

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