The metabolism of normal and tumour tissue

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Abstract
The negative dyestuff phenosafranine inhibited the Pasteur reaction in animal tissues (brain, yolk-sac, tumors) in ca. 10-5 M concn.; other negative dyes did not show this action, but a group of 2-substituted derivatives of pyridine, acridine and quinoline containing a quaternary N-atom and a conjugated chain ending usually in a basic grouping had essentially the same action on metabolism as phenosafranine, though some members were more poisonous. The activity is ascribed to an anti-catalytic action on certain cell enzymes, possibly by displacement of coenzymes from their colloidal carriers. The sarcoma-producing "styryl 430" of Browning, which is also a 2-styry]l-quinoline compound, was tested for its action on metabolism. In concns. similar to phenosafranine, it greatly increased respiration and aerobic and anaerobic glycolysis of rat brain. The possible relationship of these observations to exptl. carcinogenesis is briefly discussed.