Naturally Occurring Immunosuppressive Agents II. The Ability of Cell-Free Liver Extracts to Modify the Rejection of Allogeneic Skin Grafts in the Rabbit

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Abstract
It has been demonstrated that cell-free extracts of pig, rabbit and human liver, but not of other parenchymal organs, contain a factor or factors capable of suppressing the proliferative responses of allogeneic and xenogeneic lymphoid cells stimulated with PHA, PWM, Con-A and allogeneic lymphocytes. Intravenous injection of the liver extract is capable of modifying significantly the skin allograft rejection reaction in normal adult out-bred rabbits. Work is now in progress to isolate this factor and to determine its composition.