Caspases leave the beaten track: caspase-mediated activation of NF-κB
Open Access
- 17 April 2006
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 173 (2) , 165-171
- https://doi.org/10.1083/jcb.200509092
Abstract
The proteolytic activity of the cysteinyl aspartate–specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor κB (NF-κB), a transcription factor that fulfils a central role in innate and adaptive immunity, in cellular stress responses and in the induction of anti-apoptotic factors. Two different mechanisms by which caspases activate the NF-κB pathway are discussed.Keywords
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