RELEASE OF MONOCLONAL ANTIBODY-DEFINED ANTIGENS BY HUMAN COLORECTAL-CARCINOMA AND MELANOMA-CELLS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 41  (7) , 2723-2727
Abstract
Many, but not all, of the cell surface antigens studied were released into tissue culture medium of human colorectal carcinoma and melanoma cells maintained in vitro. Two groups of monoclonal antibody-defined antigens are described. One group is composed of molecules that are released easily and in large quantities into the tissue culture milieu. In this group, 4 glycolipid antigens of colon carcinoma, including a monosialoganglioside, and 5 glycoproteins of melanoma were detected in tissue culture supernatants. Antigens of the 2nd group could not be detected in tissue culture supernatants. This group included 1 colorectal carcinoma antigen, the nature of which is unknown, and a glycoprotein of melanoma cells.