Epimerisation-free peptide formation from carboxylic acid anhydrides and azido derivatives
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 1,p. 91-92
- https://doi.org/10.1039/c39950000091
Abstract
Conversion of C-terminal carboxy groups of N-protected α-amino acids to the corresponding 3,5-dinitrobenzoyl mixed anhydrides, followed by treatment with α-azido esters and trialkylphosphines, affords good yields of peptides, without appreciable formation of epimers even for reactions involving Phe–Val and Val–Val couplings and/or N-benzoyl α-amino acids.Keywords
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