Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS
- 1 July 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 39 (7) , 969
- https://doi.org/10.1212/wnl.39.7.969
Abstract
To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.This publication has 10 references indexed in Scilit:
- A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: 2. Laboratory results.Journal of Neurology, Neurosurgery & Psychiatry, 1987
- A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: 1. Clinical effects.Journal of Neurology, Neurosurgery & Psychiatry, 1987
- Effect of Methylprednisolone on CSF IgG Parameters, Myelin Basic Protein and Anti-Myelin Basic Protein in Multiple Sclerosis ExacerbationsCanadian Journal of Neurological Sciences, 1986
- High‐dose intravenous methylprednisolone in the treatment of multiple sclerosisNeurology, 1986
- Effect of ACTH treatment on CSF and blood lymphocyte subpopulations in patients with multiple sclerosisActa Neurologica Scandinavica, 1981
- Multiple sclerosis de novo CNS IgG synthesisNeurology, 1980
- Prolonged effects of large‐dose methylprednisolone infusion in multiple sclerosisNeurology, 1980
- LONG-TERM TREATMENT OF MULTIPLE SCLEROSIS WITH CORTICOTROPHINThe Lancet, 1967
- Further notes on disability evaluation in multiple sclerosis, with scale modificationsNeurology, 1965
- Use of an Oral Corticosteroid In the Treatment Of Multiple SclerosisArchives of Neurology, 1965