Age-Related Changes of Beta-Adrenoceptors in Aging Inbred Mice
- 30 June 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Gerontology
- Vol. 41 (4) , 439-444
- https://doi.org/10.1093/geronj/41.4.439
Abstract
The density (Bmax) and antagonist dissociation constant (KD)of beta-adrenoceptors were determined on spleen and brain of three different inbred strains of mice — BALB/cJ, C3H/HeJ, and C57BL/6J. Receptor densities (Bmax) differed with strain and declined in both spleen and cortical receptor populations as mice became older. Age-related changes in KD were found on spleen cells of BALB/cJ and in the cortex of C3H/HeJ and C57BL/6J. Bmax and KD in different organs of the same strain changed at different rates, changed at different rates.Keywords
This publication has 5 references indexed in Scilit:
- Changes of Histone Hi Subtypes With Aging in Strains of Mice That Possess Different Immunological CharacteristicsJournal of Gerontology, 1985
- Characterization of (-)-[3H]dihydroalprenolol binding to intact and broken cell preparations of human peripheral blood lymphocytesEuropean Journal of Pharmacology, 1982
- Mechanisms Involved in Age‐dependent Decline of Immune Responsiveness and Apparent Resistance against Tolerance Induction in C57BL/6 MiceScandinavian Journal of Immunology, 1982
- Polymorphism of age-dependent changes in the production of a Thf helper factorCellular Immunology, 1982
- Human Lymphocyte Beta-adrenergic Receptors Are Unaltered With AgeJournal of Gerontology, 1981