EARLY DETECTION OF AMINOGLYCOSIDE NEPHROTOXICITY WITH URINARY BETA-2-MICROGLOBULIN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 9  (3) , 201-210
Abstract
A radioimmunoassay was used to evaluate the changes in the urinary excretion of .beta.2-microglobulin (.beta.2M) in 21 patients receiving aminoglycosides for treatment of infection. Excretion of this protein rose to a peak at least 5 .times. the baseline value in the urine, and declined rapidly to control values after drug administration ceased. In 6 patients who developed aminoglycoside nephrotoxicity, urinary .beta.2M excretion rose 5 days or more before serum creatinine rose and 5 of 6 nephrotoxic patients excreted more than 50 mg/day (normal, < 0.1 mg/day). Urinary .beta.2M is a non-specific indication of renal tubular damage, but heralds aminoglycoside-induced damage before standard tests of kidney function change.

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