ANTIBODY RESPONSE TO ALPHA‐ AND BETAHEMOLYSIN FROM STAPHYLOCOCCUS AUREUS IN PATIENTS WITH STAPHYLOCOCCAL INFECTIONS AND IN NORMALS

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Abstract
Patients with S. aureus infections (119) and non-S. aureus septicemia (22) were investigated for anti-.alpha.-hemolysin antibodies using a radioimmunoassay (RIA). As compared to 160 healthy controls, patients with S. aureus endocarditis, septicemia, chronic osteomyelitis and recurrent furunculosis showed significantly higher antibody levels; the non-S. aueus septicemia group showed normal levels. Corresponding results were obtained using the conventional anti-staphylolysin test. Only patients with recurrent furunculosis had significantly elevated anti-.beta. hemolysin antibody levels assessed by RIA, in comparison with healthy control. The highest antibody levels were found in furunculosis infected with S. aureus strains which were high producers of .beta.-hemolysin. Thus, furunculosis patients do not have a defective serological response against S. aureus .beta.-hemolysin.

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