ANALGESIC AND OTHER PHARMACOLOGICAL PROPERTIES OF 1-Δ3-PIPERIDEINO-3-O-TOLOXY PROPAN-2-OL HYDROCHLORIDE (TOLPRONINE)
- 1 September 1958
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 10 (1) , 60-70
- https://doi.org/10.1111/j.2042-7158.1958.tb10273.x
Abstract
1‐Δ3‐Piperideino‐3‐o‐toloxypropan‐2‐ol hydrochloride, Tolpronine, possesses marked analgesic activity, being approximately 20 times as active as metamizolum subcutaneously and approximately 11 times as active orally. The induction time after subcutaneous injection is shorter than with metamizolum and the duration similar. Excessively large amounts constipate normal mice; a weak spasmolytic effect is seen in the isolated guinea pig ileum and rabbit duodenum. The jejunum of the anaesthetised cat shows a spasmogenic effect. Chronic administration to rats and rabbits caused a reduction in the growth rate of rats.Keywords
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