Fentanyl Pharmacokinetics in Awake Volunteers

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Abstract
A single i.v. of the narcotic analgesic fentanyl (either 2 or 4 .mu.g/kg body wt) was given to 13 healthy, young human volunteer subjects. Serum fentanyl concentration decreased in a triexponential pattern. The terminal half-times were 750 and 853 min, respectively. A 3 compartment, open, mammillary model is proposed for fentanyl kinetics.