The Effect of Long-Term Cimetidine Treatment on PRL and TSH Response Capacity to TRH in Male Patients with Duodenal Ulcer

Publisher Website
Google Scholar
Abstract
The effect of long-term cimetidine treatment for 6 mo. on basal and TRH-stimulated prolactin (PRL) and TSH secretion was studied in 8 male patients with duodenal ulcer. They received 1000 mg cimetidine orally per day until ulcer healing and thereafter 400 mg/day for the remaining period. TRH perturbation tests were performed before and after the 6 mo. of treatment. A significant reduction in the pituitary TSH response capacity was found. No significant changes in basal and TRH-stimulated PRL, basal TSH, thyroxine and triiodothyronine were found. It is uncertain if the reduction in pituitary TSH response capacity has any clinical implications in euthyroid patients.

This publication has 21 references indexed in Scilit: