4,5-Disubstituted primaquine analogues as potential antimalarial agents
- 1 September 1986
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 29 (9) , 1796-1798
- https://doi.org/10.1021/jm00159a042
Abstract
Three 4,5-disubstituted primaquine analogues were synthesized and evaluated for radical curative activity against Plasmodium cynomolgi in rhesus monkeys. One of the compounds showed moderate activity; however, none of the three compounds were as active as the lead compounds 5-methoxy-4-methylprimaquine and 4-(methoxy-methyl)-5-[m-(trifluoromethyl)phenoxy]primaquine.This publication has 6 references indexed in Scilit:
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