EFFECTS OF CENTRALLY AFFECTING DRUGS ON THE DIURETIC AND ANTIDIURETIC ACTIONS OF INTRACEREBROVENTRICULAR PROSTAGLANDIN E2
Open Access
- 1 January 1978
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 28 (1) , 49-56
- https://doi.org/10.1254/jjp.28.49
Abstract
Effects of centrally affecting drugs on the diuretic and antidiuretic actions of intracerebroventricularly (i.c.v) injected prostaglandin(PG)E2 in ethanol-anesthetized rats were studied. PGE2, when injected i.c.v. at a dose of 1 nmol, produced diuresis followed by antidiuresis. When morphine (0.1 mM) was perfused i.c.v., urine outflow decreased and neither diuretic nor antidiuretic effects of i.c.v. PGE2 was apparent. The perfusions with picrotoxin,.gamma.-aminobutyric acid and L-glutamate inhibited either the diuretic or the antidiuretic effect of PGE2. When pentobarbital, diazepam, isoniazid and strychnine were perfused i.c.v., the diuretic action of PGE2 was diminished and antidiuresis in response to PGE2 remained unchanged. The diuretic and antidiuretic effects of PGE2 apparently could be separated. The development of the diuretic effect of PGE2 was completely blocked by amitiriptyline and antidiuresis was increased. In rats pretreated i.c.v. with reserpine, the diuretic effect of PGE2 was prolonged and antidiuresis in response to PGE2 was not observed. An antidiuretic action of i.c.v. norepinephrine was not varied by reserpine. Mechanisms for both effects of PGE2 are discussed.This publication has 30 references indexed in Scilit:
- Roles for the prostaglandins in the regulation of anterior pituitary secretionLife Sciences, 1977
- Centrally-Mediated Effects of Prostaglandin A2 on Urine Outflow.The Japanese Journal of Pharmacology, 1977
- VASOPRESSIN RELEASE DURING VENTRICULO-CISTERNAL PERFUSION WITH PROSTAGLANDIN E2 IN THE DOGJournal of Endocrinology, 1976
- Influence of Prostaglandin E1 on Cerebral Mechanisms Involved in the Control of Fluid BalanceActa Physiologica Scandinavica, 1976
- INHIBITORY EFFECT OF PROSTAGLANDIN F2α ON OXYTOCIN RELEASE AND ON MILK EJECTION IN LACTATING RATSJournal of Endocrinology, 1976
- Release of ADH by glutamic acid analogues from the isolated neurohypophysis and their central antidiuretic action in ratsThe Japanese Journal of Pharmacology, 1976
- Effects on Fluid Balance of Intraventricular Infusions of Prostaglandin E1Acta Physiologica Scandinavica, 1975
- PROSTAGLANDINS AND NEURONAL ACTIVITY IN SPINAL CORD AND CUNEATE NUCLEUSAnnals of the New York Academy of Sciences, 1971
- Correlation of prostaglandin release from the cerebral cortex of cats with the electrocorticogram, following stimulation of the reticular formationBritish Journal of Pharmacology, 1969
- Spontaneous and evoked release of prostaglandins from cerebral cortex of anesthetized catsAmerican Journal of Physiology-Legacy Content, 1966