THE EFFECTS ON RENAL ACTIVITY OF THE ORAL ADMINISTRATION OF PHLORIZIN IN MAN

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Abstract
Simultaneous clearances were determined of urea, xylose and creatinine in normal man, before phlorizin, and in addition glucose clearance after phlorizin administration. The phlorizin (150-400 mgm. per kgm.) was administered orally. Following the larger doses there was a significant depression of the urea, xylose and creatinine clearances. There were no lasting toxic effects. The oral administration of phlorizin produced a transient glycuresis, but the largest dose (approximately 32 gm. administered in divided doses over a period of 3 hrs.) was insufficient to raise the glucose clearance to the level of the xylose clearance, nor did it significantly depress the creatinine-xylose ratio.

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