The Fibrinolytic Activity of Human Endometrium, Studied in Tissue Culture: Part I, Normal Endometrial and Decidual Tissue

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Abstract
Endometrial tissue obtained at curettage and decidual tissue from Cesarean sections or therapeutic abortion were grown in Tyrode fluid containing plasma- chick embryo extract with and without lysine ethyl ester and the cellular outgrowth was observed by phase microscopy. The fibrinolytic process was studied by the number of explants showing a complete digestion of the surrounding plasma and becoming loose. Endometrium from women with normal menstrual cycles showed a strong fibrinolytic activity, both in the secretory and proliferative phases. Lysine ester produced a moderate retardation of fibrinolytic activity of secretory phase and a marked retardation in the proliferative phase. Senile endometrium and decidual tissue after the 3rd month of gestation showed little or no fibrinolytic activity.