Antigenized antibodies
- 1 January 1992
- journal article
- Published by Springer Nature in Nature
- Vol. 355 (6359) , 476-477
- https://doi.org/10.1038/355476a0
Abstract
A new process, antigenization of antibodies, consisting of the expression of oligopeptides in the hypervariable loops of an antibody molecule is described. The potential applications of antigenized antibodies are discussed.Keywords
This publication has 27 references indexed in Scilit:
- Progress Toward Malaria Preerythrocytic VaccinesScience, 1991
- Random Peptide Libraries: a Source of Specific Protein Binding MoleculesScience, 1990
- Searching for Peptide Ligands with an Epitope LibraryScience, 1990
- Fimbriae of Bacteroides nodosus: protein engineering of the structural subunit for the production of an exogenous peptideProtein Engineering, Design and Selection, 1989
- Reshaping Human Antibodies: Grafting an Antilysozyme ActivityScience, 1988
- Reshaping human antibodies for therapyNature, 1988
- Replacing the complementarity-determining regions in a human antibody with those from a mouseNature, 1986
- Antigen-antibody interactions at the molecular level: adventures in peptide synthesisImmunology Today, 1985
- Domain association in immunoglobulin moleculesJournal of Molecular Biology, 1985
- Different degrees of interspecies homology in immunoglobulin λ chain constant domain correlated with three-dimensional structureNature, 1975