Effect of Food and Water on Thyroid Uptake of Radioiodine (I131) in Rats

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Abstract
Summary 1. Data have been presented which show that intake of food and water, and water alone, ínfluence the uptake of radioactive iodine in the thyroid gland of rats on an iodine deficient diet of Remington and Levine. At 6 and 24 hours, the thyroid uptake is reduced significantly if water is given. An even more profound reduction in uptake and correspondingly increased excretion has been observed if both food and water are allowed. 2. It has been suggested that gastric activity and fluid intake should be controlled when radioactive iodine uptake is to be used for evaluating and treating thyroid disease.