Chance, necessity and antibody gene dynamics
- 1 May 1983
- journal article
- Published by Springer Nature in Nature
- Vol. 303 (5912) , 23-26
- https://doi.org/10.1038/303023a0
Abstract
Early in their development B lymphocytes commit themselves to the expression of only one immunoglobulin light-chain gene and only one heavy-chain gene out of the large numbers of available loci. Here I shall present the view that the initial selection of loci for expression is made by chance, whereas the exclusion of other loci from expression is a necessity imposed by the physiology of lymphocyte development.Keywords
This publication has 39 references indexed in Scilit:
- Unusual association of V, J and C regions in a mouse immunoglobulin λ chainNature, 1982
- The relationship between pre-B cells and primary B cellsImmunology Today, 1982
- Organization and Expression of Murine Immunoglobulin GenesImmunological Reviews, 1981
- Recombination events near the immunoglobulin C.mu. gene join variable and constant region genes, switch heavy-chain expression, or inactivate the locusBiochemistry, 1981
- CH gene rearrangements in IgM-bearing B cells and in the normal splenic DNA component of hybridomas making different isotypes of antibodyCell, 1980
- Variation in the crossover point of kappa immunoglobulin gene V-J recombination: Evidence from a cryptic geneCell, 1980
- Functional and non-functional joining in immunoglobulin light chain genes of a mouse myelomaNature, 1980
- The organization and expression of immunoglobulin genesImmunology Today, 1980
- Transformation of Immature Lymphoid Cells by Abelson Murine Leukemia VirusImmunological Reviews, 1979
- Differentiation of lymphocytes in mouse bone marrow: II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labelingCellular Immunology, 1974