Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma
- 30 September 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 287 (5783) , 603-607
- https://doi.org/10.1038/287603a0
Abstract
Leader, variable (V) and joining (J) gene segments, and adjacent regions of 2 rearranged alleles of the same .kappa.-chain producing mouse myeloma, comprising approximately 3,200 base pairs, were sequenced. Sequence comparisons are reported. V-J joining in 1 of the alleles leads to a reading frame with a stop codon within the J-gene segment. Allelic exclusion is apparently realized in this tumor through the formation of such a non-functional allele.Keywords
This publication has 31 references indexed in Scilit:
- A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing eventsNature, 1980
- An unusual translocation of immunoglobulin gene segments in variants of the mouse myeloma MPC11Nature, 1980
- V–J joining of immunoglobulin κ genes only occurs on one homologous chromosomeNature, 1980
- Sequences at the somatic recombination sites of immunoglobulin light-chain genesNature, 1979
- Sequences of mouse immunoglobulin light chain genes before and after somatic changesCell, 1978
- Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genesBiochemistry, 1978
- Cloned MPC 11 myeloma cells express two kappa genes: a gene for a complete light chain and a gene for a constant region polypeptideCell, 1977
- Determination of the Primary Structure of a Mouse IgG2a ImmunoglobulinEuropean Journal of Biochemistry, 1975
- Synthesis of a carboxyl-terminal (constant region) fragment of the immunoglobin light chain by a mouse myeloma cell lineJournal of Molecular Biology, 1974
- CELLULAR LOCALIZATION OF IMMUNOGLOBULINS WITH DIFFERENT ALLOTYPIC SPECIFICITIES IN RABBIT LYMPHOID TISSUESThe Journal of Experimental Medicine, 1965