A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events
- 1 August 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 286 (5775) , 779-783
- https://doi.org/10.1038/286779a0
Abstract
A mutant immunoglobulin gene has been formed by an abnormal (non V/J) recombination event such that abnormal RNA splicing is required to form a mutant light chain. The structure of the gene suggests that the small palindrome thought to be involved in V/J joining also provides the basis for this abnormal DNA recombination and that the absence of a J segment and RNA splice signal allows an abnormal RNA splicing reaction to occur.This publication has 26 references indexed in Scilit:
- A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutationNature, 1979
- Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.Proceedings of the National Academy of Sciences, 1979
- Sequences at the somatic recombination sites of immunoglobulin light-chain genesNature, 1979
- The arrangement and rearrangement of antibody genesNature, 1978
- A complete immunoglobulin gene is created by somatic recombinationCell, 1978
- Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis.Proceedings of the National Academy of Sciences, 1978
- Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNACell, 1978
- Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.Proceedings of the National Academy of Sciences, 1976
- Amino acid-sequence variability at the N-terminal extra piece of mouse immunoglobulin light-chain precursors of the same and different subgroupsBiochemical Journal, 1976
- The molecular basis of antibody formation: a paradox.Proceedings of the National Academy of Sciences, 1965