Oxidative stress and antioxidant protection in the perinatal period
- 1 May 2007
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Clinical Nutrition and Metabolic Care
- Vol. 10 (3) , 324-328
- https://doi.org/10.1097/mco.0b013e3280a94f6d
Abstract
Oxidative stress is implicated in the pathophysiology of disorders during pregnancy, childbirth and the postnatal period, but open questions exist on the effects of antioxidants, the role of oxidative stress during resuscitation and the antioxidative protection of human milk. In a randomized controlled trial, fish oil supplementation to pregnant women did not enhance oxidative stress. Two randomized controlled trials supplementing high dosages of both vitamins C and E did not show any reduction in the incidence of preeclampsia. A systematic review and meta-analysis of studies comparing resuscitation of asphyxiated infants either with 100% oxygen or with room air demonstrated significantly lower neonatal mortality with use of room air. Antioxidative properties of human milk were greater in milk from mothers of term than of preterm infants. Increased levels of oxidative stress and reduced antioxidative capacities may contribute to the pathogenesis of disorders in the perinatal period. Based on the available evidence, supplementation of pregnant women with high dosages of both vitamin C and E cannot be recommended. Asphyxiated newborn infants should be resuscitated with room air rather than with 100% oxygen. Breastfeeding appears beneficial in providing antioxidative protection.Keywords
This publication has 29 references indexed in Scilit:
- Vitamins C and E and the Risks of Preeclampsia and Perinatal ComplicationsNew England Journal of Medicine, 2006
- Coenzyme Q concentration and total antioxidant capacity of human milk at different stages of lactation in mothers of preterm and full-term infantsFree Radical Research, 2006
- Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancyFree Radical Research, 2006
- Correlation between circulating biomarkers of oxidative stress of maternal and umbilical cord blood at birthFree Radical Research, 2006
- The Role of Placental Oxidative Stress and Lipid Peroxidation in PreeclampsiaObstetrical & Gynecological Survey, 2005
- Oxidative stress in the fetal circulation does not depend on mode of deliveryAmerican Journal of Obstetrics and Gynecology, 2005
- Resuscitation of Depressed Newborn Infants with Ambient Air or Pure Oxygen: A Meta-AnalysisNeonatology, 2005
- Placental defence is considered sufficient to control lipid peroxidation in pregnancyMedical Hypotheses, 2004
- Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentaePlacenta, 2004
- Oxidative stress in childhood—in health and disease statesClinical Nutrition, 2004