Immunoglobulin G heavy chain (Gm) allotypes in multiple sclerosis.
Open Access
- 1 June 1981
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 67 (6) , 1797-1800
- https://doi.org/10.1172/jci110220
Abstract
Serum samples from 70 Caucasian patients with multiple sclerosis were typed for nine Gm markers. Significant association was found with the Gm 1,17;21 phenotype, and the relative risk for individuals with this phenotype was calculated at 3.6. The data indicate that Caucasians positive for Gm 1,17;21 are almost four times more likely to develop multiple sclerosis than those without this phenotype.This publication has 29 references indexed in Scilit:
- Defective immunoreguktion in multiple sclerosisAnnals of Neurology, 1980
- Linkage between the frequency of muscular weakness and loci that regulate immune responsiveness in murine experimental myasthenia gravis.The Journal of Experimental Medicine, 1980
- Oligoclonal IgG and free light chains in multiple sclerosis demonstrated by thin‐layer polyacrylamide gel isoelectric focusing and immunofixationAnnals of Neurology, 1980
- Loss of Suppressor T Cells in Active Multiple SclerosisNew England Journal of Medicine, 1980
- IgG subclasses, barrier function for albumin and production of immunoglobulin G in the central nervous systemActa Neurologica Scandinavica, 1979
- Suppressor cell function in multiple sclerosis: Correlation with clinical disease activityAnnals of Neurology, 1979
- Population genetics of the human allotypes Gm, Inv, and A2mClinical Immunology and Immunopathology, 1977
- Criteria for the clinical diagnosis of multiple sclerosisNeurology, 1976
- IgG1 Subclass Restriction of Oligoclonal IgG from Cerebrospinal Fluids and Brain Extracts in Patients with Multiple Sclerosis and Subacute EncephalitidesScandinavian Journal of Immunology, 1976
- ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASEAnnals of Human Genetics, 1955