THE ‘TRANSITION PROBABILITY MODEL’ AND THE REGULATION OF PROLIFERATION OF HUMAN DIPLOID CELL CULTURES DURING AGING
- 1 July 1976
- journal article
- research article
- Published by Wiley in Cell Proliferation
- Vol. 9 (4) , 395-399
- https://doi.org/10.1111/j.1365-2184.1976.tb01288.x
Abstract
Genealogies derived from time-lapse cinemicrophotographic studies of aging human diploid cell cultures were analyzed in terms of the transition probability model. The distribution of intermitotic times obtained from middle passage cells deviated only slightly from that predicted by the model. In contrast, the plot for late passage cultures did not fit the predicted pattern and appeared to be composed of multiple curves. These changes are discussed in reference to cellular senescence as expressed by normal human diploid cells in vitro.This publication has 13 references indexed in Scilit:
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