DIRECT DETECTION OF USUAL AND ATYPICAL ALLELES ON THE HUMAN ALDEHYDE DEHYDROGENASE-2 (ALDH2) LOCUS
- 1 December 1987
- journal article
- research article
- Vol. 41 (6) , 996-1001
Abstract
A method for determining human mitochondrial aldehyde dehydrogenase (ALDH2) genotypes were developed. Two 21-base synthetic oligonucleotides, one complementary to the usual ALDH21 gene and the other complementary to the atypical ALDH22 gene, were used as specific probes for in-gel hybridization analysis of human genomic DNA from either peripheral blood cells or livers. Under appropriate hybridization conditions, these two probes can hybridize to their specific complementary alleles and thus allow the genotyping of the ALDH2 locus.This publication has 18 references indexed in Scilit:
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