The stimulation of bone marrow granulopoiesis of normal CBA mice in vitro and in vivo by serum obtained from leucophoretic rats

Publisher Website
Google Scholar
Abstract
The effect of leukophoretic serum (LS), obtained from rats with polyvinylpyrrolidone(PVP)-induced inflammation, on granulopoiesis in the bone marrow of normal CBA mice was studied. The following test systems were used: short-term cultures (4 h), diffusion chambers (8, 24, 48 and 72 h) and in vivo assays (12, 24 and 48 h). LS apparently stimulates the proliferations of granulocytic cells by increasing the number of proliferative granulocytes in mitosis as well as the total number of proliferative granulocytes. LS did not appear to affect monocytes and other cell lines. A factor present in LS specifically stimulates the proliferation of granulocytic cells both in vitro and in vivo.