Expression of Embryonic Characters by Malignant Cells
- 1 January 1983
- book chapter
- Published by Wiley
- Vol. 96, 4-27
- https://doi.org/10.1002/9780470720776.ch2
Abstract
While the expression of fetal characters by malignant cells is now well-documented, the mechanism involved and the nature of the cells that are the target of malignant transformation remain controversial. It has often been assumed that carcinogenesis results in 'dedifferentiation' of specialized cells. The alternative hypothesis is that neoplasia results from a disorder of some normal stem cells. This view is discussed in relation to several examples, in particular teratocarcinomas.Keywords
This publication has 65 references indexed in Scilit:
- Neural differentiation following culture of embryonal carcinoma cells in a serum-free defined mediumDevelopmental Biology, 1981
- Bone-forming cell line derived from embryonal carcinoma cellsNature, 1980
- The differentiation and function of human T lymphocytesCell, 1980
- The induction of differentiation in teratocarcinoma stem cells by retinoic acidCell, 1978
- Phenotypic diversity in experimental hepatomas: the concept of partially blocked ontogeny. The 10th Walter Hubert LectureBritish Journal of Cancer, 1978
- The Leeuwenhoek Lecture, 1977 Mouse teratocarcinoma and mouse embryoProceedings of the Royal Society of London. B. Biological Sciences, 1978
- ABSENCE OF SEROLOGICALLY DETECTABLE H-2 ON PRIMITIVE TERATOCARCINOMA CELLS IN CULTURETransplantation, 1974
- The development of teratomas from parthenogenetically activated ovarian mouse eggsDevelopmental Biology, 1974
- Localization of alpha‐fetoprotein in transplantable murine teratocarcinomasInternational Journal of Cancer, 1973
- The development of transplantable teratocarcinomas from intratesticular grafts of pre- and postimplantation mouse embryosDevelopmental Biology, 1970