A Comparison of ePTFE Membranes Alone or in Combination with Platelet‐Derived Growth Factors and Insulin‐Like Growth Factor‐I or Demineralized Freeze‐Dried Bone in Promoting Bone Formation Around Immediate Extraction Socket Implants

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Abstract
The purpose of this study was to compare bone promotion around implants which were augmented with ePTFE membranes alone or in combination with cortical demineralized freeze‐dried bone (DFDB) or the combination of platelet derived growth factor‐BB (PDGF) and insulin like growth factor I (PDGF/IGF‐I). Membranes were placed over titanium implants which had been inserted into fresh extraction sockets with large buccal dehiscences. Twenty‐four implants were placed in 4 dogs. At 18 weeks clinical bone height measurements were taken, the animals were sacrificed, and all specimens retrieved for histologic evaluation. Clinically, a significant gain in bone levels was present in both the ePTFE membrane alone group (P < 0.005) and PTFE plus PDGF/IGF‐I group (P J Periodontol 1992;63:929– 940.