LYMPHOCYTE CELL SUB-POPULATIONS DURING ACUTE POST-STREPTOCOCCAL GLOMERULONEPHRITIS - CELL-SURFACE ANTIGENS AND BINDING OF STREPTOCOCCAL MEMBRANE-ANTIGENS AND C-REACTIVE PROTEIN

  • 1 January 1981
    • journal article
    • research article
    • Vol. 46  (2) , 397-405
Abstract
T lymphocyte surface markers were examined in 23 patients with acute post-streptococcal glomerulonephritis (AGN) in parallel with normal controls and individuals without nephritis who showed evidence of pharyngeal or skin-sore .beta.-hemolytic streptococcal infection. Numbers of T.gamma. cells were similar in AGN and normal controls but were significantly lower (P < 0.05) than those in skin-sore culture-positive streptococcal infection controls. Numbers of T.mu. cells were similar in AGN and normal controls but were lower (P < 0.05) than those observed in streptococcal controls. Percentages of T.mu. cells were similar in AGN and normal controls but were lower (P < 0.05) than those recorded in streptococcal infection control groups. Proportions of T cells were reduced during AGN (P < 0.05). Lymphocytes capable of binding type 12 group A streptococcal membranes were increased (30.4%) in patients with AGN as compared to normal controls (4.1%). Subjects with streptococcal infection alone showed elevated but intermediate relative numbers (10.5%) of lymphocytes binding group A membranes. Increased relative numbers of both B and T lymphocytes binding group A streptococcal membranes were present in both AGN and non-nephritogenic streptococcal infection controls.

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