Alpha-1-antitrypsin deficiency and hepatocellular carcinoma.
Open Access
- 1 April 1979
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 32 (4) , 373-376
- https://doi.org/10.1136/jcp.32.4.373
Abstract
Forty-two cases of hepatocellular carcinoma (HCC) were examined for the presence of the inclusions of alpha-1-antitrypsin (AAT), which indicate a carrier state for the Pi Z gene. These were found in the non-neoplastic liver tissue of two cases of HCC and in one of the 98 control livers, a difference that is not statistically significant. Typical globules of AAT deficiency were not found in HCC cells. One-quarter of HCCs, however, contained cells which showed diffuse cytoplasmic staining for AAT, a pattern seen also in the non-neoplastic livers.This publication has 20 references indexed in Scilit:
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