Interactions of HIV‐1 with antigen‐presenting cells
- 1 August 1999
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 77 (4) , 289-303
- https://doi.org/10.1046/j.1440-1711.1999.00833.x
Abstract
There is currently much interest in the numerical and functional loss of antigen-presenting cells (APC) in HIV-1 disease and the contribution that this may make to HIV-1 pathology. The HIV-1 virus can interfere with the normal function of APC in a number of ways involving inappropriate signalling. These include changes in cytokine balance, cell-surface molecule expression and intracellular signalling pathways. This review examines how HIV-1 is able to disregulate APC function and discusses possible outcomes for the function of the immune system.Keywords
Funding Information
- AIDS Education and Research Trust
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