Brain Pathology in the Collagen Vascular Diseases

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Abstract
Neuropathologic examination of autopsies of 54 patients of various types of CVD [collagen vascular disease] revealed a very high frequency of pathologic changes both in brain parenchyma (81%) and vessels (78%). A broad but continuous spectrum of primary vascular alterations was observed, ranging from fibrinoid deposits in intact or necrotizing vessel walls to fibrohyalinosis and endothelial proliferations. In acute SLE [systemic lupus erythematosus] showing LE cells within brain tissues, immune complex deposits were observed for the 1st time in brain vessels, in addition to similar deposits in the plexus choroideus and in hematoxylin bodies. Secondary complications frequently affect the brain in CVD; they are mainly sequels of systemic atherosclerosis, hypertension, thromboemboli from SLE endocarditis, cardiac, hepatic or renal dysfunctions or infections and should be clinically differentiated from primary brain involvement in CVD to ensure the appropriate therapeutic measures.