Quantitation of Erythropoiesis in Myelomatosis

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Abstract
Quantitation of the erythropoiesis with radio-Fe (59Fe) was applied to 9 patients with untreated myelomatosis. The method included blocking of the 59Fe reutilization by injection of non-radioactive Fe. There was no uniform pattern in the Fe-kinetics values. The plasma Fe turnover (PIT) and the red blood cell Fe turnover (RBCIT) varied from subnormal to values markedly increased above upper normal limit. The calculated average mean red cell life time (MRCL) of erythrocytes was just below normal range. The mean marrow transit time (MTT) was normal in the patients, despite subnormal venous hematocrit, indicating insufficient stimulation of the bone marrow. The renal function, measured as 51Cr-EDTA clearance, was positively correlated to the RBCIT (r [correlation coefficient] = 0.78, P < 0.05). The previously demonstrated relationship between anemia and renal failure in patients with myelomatosis was caused mainly by an inability of the bone marrow to produce sufficient red blood cells under the stress of anemia related to the degree of renal impairment.

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