Quantitation of Erythropoiesis by a new Method. Studies on Healthy Subjects

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Abstract
The percentage of plasma iron transported per day in the human and incorporated into the circulating erythrocytes becomes a quantitative measure of effective erythropoiesis if re-circulation of radioiron is efficiently blocked. This was achieved by intravenous injections of 100 mg doses of inactive iron given 8 hr., 1. 4, and 7 days after radioiron injection. The life time of the erythrocytes in 5 normal individuals calculated from data obtained in this way has a mean value of 102 days. The findings point to a maturation time of the erythrocyte amounting to 7 days. The results obtained contradict the existence of a labile erythropoietic bone marrow pool.