Age Changes in Endosteal Bone Remodeling and Balance in the Rabbit

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Abstract
Metabolically normal rabbits, like humans, have specific surface changes in bone remodeling and balance with age. The loss of cortical bone with aging is primarily caused by an endosteal surface negative balance. Since formation rates on these surfaces remain relatively constant with aging, this negative bone balance is the result of increased osteoclastic cell activity. The specific mechanism of this increased osteoclastic activity is not known.