EGF binding is quantitatively related to growth in node-positive breast cancer
- 1 September 1988
- journal article
- research article
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 12 (1) , 45-49
- https://doi.org/10.1007/bf01805739
Abstract
Number of mitoses and EGF binding were determined in parallel in biopsies of 27 lymph-node positive and of 23 lymph-node negative breast cancer patients. For node-positive patients the parameters for cell growth and EGF binding were quantitatively correlated by the equation y = P3 + P1(1 − exp( − P2x)). For node-negative cases neither the non-linear model nor the linear approximation described the data unambiguously. The results strongly suggest that in node-positive patients, growth of breast cancer is related to an EGF-dependent acceleration of cell division.This publication has 19 references indexed in Scilit:
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