PHARMACOLOGICAL COMPARISON OF ISOLATED BRONCHIAL ARTERY AND PULMONARY VEIN - POSSIBLE FUNCTIONAL RELATIONSHIPS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 26  (2) , 227-241
Abstract
Using selective agonists and antagonists, active .alpha. and .beta., adrenoceptors and muscarinic cholinoceptors were identified in isolated strips of [bovine] bronchial artery and pulmonary vein. Beta2 receptors were located in the bronchial artery only. The bronchial artery was more sensitive to phenylephrine and less sensitive to carbachol than the corresponding pulmonary vein, which was in turn more sensitive to the spasmogenic action of serotonin, SRS-A [slow-releasing substance of anaphylaxis] and prostaglandins than the artery. Both vessels contained histamine H1-receptors and tryptamine D-receptors. Histamine H2-receptors were confined to the pulmonary vein. The data were consistent with the involvement of bronchial and pulmonary vasculature in allergic pulmonary diseases.