A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery
Top Cited Papers
- 1 January 2000
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 89 (1) , 16-35
- https://doi.org/10.1002/(sici)1520-6017(200001)89:1<16::aid-jps3>3.0.co;2-e
Abstract
No abstract availableKeywords
This publication has 75 references indexed in Scilit:
- A physiologically based pharmacokinetic model for nicotine and cotinine in manJournal of Pharmacokinetics and Biopharmaceutics, 1992
- Prediction of Glycyrrhizin disposition in rat and man with liver failure by a physiologically based pharmacokinetic model.Journal of Pharmacobio-Dynamics, 1990
- Constant-rate infusion of nicotine and cotinine. I. A physiological pharmacokinetic analysis of the cotinine disposition, and effects on clearance and distribution in the ratJournal of Pharmacokinetics and Biopharmaceutics, 1987
- Age-dependent changes in phenytoin tissue distribution in rats.Journal of Pharmacobio-Dynamics, 1987
- Age-dependent changes in phenytoin tissue bindings in rats: Comparison between in vivo and in vitro tissue-to-blood partition coefficients (Kp values) of phenytoin.Journal of Pharmacobio-Dynamics, 1987
- Fundamental pharmacokinetic properties of biperiden: tissue distribution and elimination in rabbits.Journal of Pharmacobio-Dynamics, 1986
- In vitro andin vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic modelsJournal of Pharmacokinetics and Biopharmaceutics, 1982
- Influence of Ventilation on Response to Fluid Load in DogsAnesthesiology, 1982
- Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital, and thiopental in the ratJournal of Pharmacokinetics and Biopharmaceutics, 1982
- Controlled release of tetracycline—III: A physiological pharmacokinetic model of the pregnant ratJournal of Pharmacokinetics and Biopharmaceutics, 1980