Serum Lipoprotein Stability in Atherosclerosis

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Abstract
The alpha toxin of Clostridium welchii is a potent lecithinase which disrupts the serum lipoproteins, eventually resulting in complete separation of the lipids from the protein fraction. This reaction is associated with the development of turbidity, the intensity of which is related to the quantitative level of serum lipids. The time of onset of turbidity, however, appears to relate to the stability of the serum lipoprotein bond. Individuals with coronary disease showed early development of turbidity and high final turbidity in 64 per cent as compared with 14 per cent in a control group and 6 per cent in a group of young normal subjects.